"A very healthy immune system can even destroy full-blown clinical cancers." - Dr. Richard Passwater, page 52 in "Live Better, Longer" (2007)
Problems with the p53 gene are common to many cancers. The p53 gene is involved in regulating "apoptosis" (normal cell death). The WEB study (3,286 women) found p53 mutations in 25.6% of the cases, 95% were point mutations (change of a single base nucleotide). p53 mutations are most commonly associated with ER-/PR-, higher BMI and higher grade, poorly differentiated tumors. These aggressive cases tend to have far high risk of death from the cancer.
These therapies have been shown to improve or restore proper p53 function:
- Vitamin D
- Thyroid Hormone
- Phenethyl isothiocyanate(PETIC) (found in cruciferous vegetables)
Decades ago, Linus Pauling's brilliant work pointed out the huge benefits of vitamin C in relationship to cancer. Although flawed studies attempted to discredit Pauling's work, recent studies have confirmed Pauling was correct. Another new study was reported in the July 2009 issue of Carcinogenesis which showed dramatic benefit of vitamin C for estrogen sensitive breast cancer (cut incidence in half and of significantly less severity - of the rats given estradiol, the tumor incidence was reduced from 82% to 29% in those also given vitamin C, the tumors in the vitamin C group were also mostly encapsulated as opposed to invasive) .
Vitamin D status has a very strong correlation with cancer incidence. Raising vitamin D levels from 25 ng/mL to 30 ng/mL has been shown to reduce breast cancer incidence by 30%. Further data, when extrapolated, points to an 83% reduction when vitamin D levels are raised to 50 ng/mL.
Research has shown that inadequate vitamin D can result in a loss of stickiness between cells as well as a loss of differentiation, which causes cells to revert to a stem cell-like state. This results in a loss of communication between cells and potentially the start of cancer. [Cedric Garland Annals of Epidemiology]
Calcium-D-glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by mammals, including humans. "D-glucarates not only suppress cell proliferation and inflammation, but also induce apoptosis. By supplementing D-glucarates, one can favor the body's natural defense mechanism for eliminating carcinogens and tumor promoters and their effects." [2008 PubMed 18772850]
Calcium-D-glucarate inhibits protein tyrosine kinase-C activity and induces transformation growth factor beta, possibly resulting in an increase in cellular differentiation and slower progression through the cell cycle.
"Preliminary results are quite encouraging and due to calcium-D-glucarates excellent safety profile, it may be a more effective option than tamoxifen, which has numerous side effects." [Phase I trial at Memorial Sloan Kettering Cancer Center]
Calcium-D-glucarates inhibition of betaglucuronidase activity results in elimination of estrogens before they can be reabsorbed and has been shown to lower serum estrogen levels in rats by 23 percent. LDL levels are also lowered by 30 to 35 percent.
Taking Calcium-D-glucarate may increase elimination of many drugs, thus reducing their potency. No adverse effects have been observed. Recommended oral dosage is 1500 to 3000 mg per day. At an approximate cost of 12 cents per 200 mg, a dosage of 2000 mg per day would cost about $1.20.
"...treatment with 125 mg/kg DHA inhibited tumor growth by 38 percent compared to untreated animals, 250 mg/kg suppressed tumor growth by 79 percent, which was a greater effect than that of cisplatin..." [Cell Division Journal published April 2, 2009]
Estrogen Levels & Supplementation
Some women have ER+ breast tumors and yet have low levels of estrogen. Supplementation of estrogen can benefit these women without encouraging the cancer because estrogen production in the breast is many times higher than circulating estrogen. Reminder: only supplement with bioidentical estrogen, not synthetic estrogens! [primary source: Dr. Khalid Mahmud]
Compounding this issue can be the confusing case of a woman that is "estrogen dominant" and yet has low levels of estrogen and an ER+ tumor. In this case the woman is estrogen dominant due to a lack of progesterone and could benefit from supplementation of both estrogen and progesterone (primarily she needs progesterone). The progesterone is very important to counter the effects of the estrogen. It may be best to apply the progesterone directly to the breast. Some women may only apply the progesterone to the breast with the tumor but it might be a good idea to also apply it to the other breast to prevent a secondary tumor.
Glutamic acid is an excitatory neurotransmitter, GABA opposes glutamic acid with a calming effect. GABA can be formed from glutamic acid, synthesis of GABA declines with age (this can be corrected with manganese supplementation). Glutamine provides fuel for cell growth of tumors. Lower levels of glutamine in a vegetarian diet may be part of the reason a vegetarian diet combats cancer. GABA exhibits some anticancer properties. Thus it may be beneficial to increase GABA levels and encourage synthesis of GABA from glutamic acid. In this manner, manganese supplementation may be beneficial to combat cancer.
One gram of Korean ginseng per day for three years (and followed up for eight years) resulted in a 65% reduction in risk of cancer. [Yun TK, et al. Non-organ-specific preventive effect of long-term administration of korean red ginseng extract on incidence of human cancers. J Med Food. 2010 Jun;13(3):489-94.]
Green tea kills breast cancer cells in ten different ways.
Honokiol, a tree bark which is an excellent antioxidant, with anti-angiogenesis properties, and interferes with phospholipase D. It is recommended to take it with modified citrus pectin.
Body temperatures of 104 to 105 degrees will kill cancer cells. In a clinical setting this is usually combined with some form of low dose toxic therapy.
I3C, a substance found in broccoli, promotes healthy estrogen metabolism and kills cancer cells. I3C destroys Cdc25A, a molecule essential for cell division and proliferation.
Most supplements only contain iodide. The thyroid needs iodide but other body tissues, specifically the breasts, require iodine. An important role for iodine is the conversion of 16-hydroxyestrone to estriol. [sources: Abraham, Brownstein, Flechas and Jonathan Wright]
Extremely impressive results, in humans (liver cancer), have been achieved with Vitamin K2. Very good results (again in humans) have been shown with Vitamin K3 (in combination with vitamin C) and prostate cancer.
Melatonin is a hormone produced during the night which encourages sleep and turns on the body's repair functions.
Artemisinin (or Qinghaosu (pronounced: Ching-hao-su))
Artemisinin has been used for the treatment of malaria. The artemisinin molecule reacts with iron to form free radicals. Because tumor cells have a very high uptake of iron this works to "poison" the cancer cells.
Comparison of Artemisinin vs other treatments on Leukemia cells
|Artemisinin 200 uM for 8 hours||100%|
|Hyperthermia 44 degrees C for 1 hr||5%|
|Hydrogen Peroxide 176 uM (24 hr incubation)||40%|
|Mitoxantrone 0.5 uM (24 hr incubation)||55%|
|Novobiocin 800 uM (24 hr incubation)||23%|
|Sodium Ascorbate 2000 uM (24 hr incubation)||63%|
|X-ray 100 rads (24 hr incubation)||10%|
Tests on breast cancer cells were very encouraging. Artemisinin had no effect on normal breast cells. Artemisinin is 15 to 40 times more selective (targets cancer cells over normal cells) than typical chemotherapy drugs. After 16 hrs treatment cell count was only 2% of the initial amount.
Artemisinin down regulates estrogen receptor alpha while not reducing estrogen receptor beta (in human MCF7 breast cancer cells). This is another method of action which artemisin uses to fight cancer.
Artemisinin should be taken once a day at bedtime (when the immune system is lowest and cancer cells are reproducting fastest) on an empty stomach (so that it doesn't react with any iron in food in the GI tract).
The half life of artemisinin is three to four hours. Artemisinin is rapidly absorbed and peak plasma levels occur in one to two hours.
Artemisinin should not be combined with radiation therapy! (wait at least two weeks after radiation therapy before starting artemisinin)
Smokers should not use artemisinin! (smoking makes normal cells sensitive to being killed by artemisinin)
Vitamin C helps with absorption of iron and can convert ferric (Fe3) iron to ferrous (Fe2) iron (artemisinin reacts with ferrous iron).
Side Effects: some patients complain of itchy skin at 1 to 2 mg/kg/day dosage. Combination forms (artemisinin + artesunate + artemether) are slightly more effective but have undesirable side effects (anemia, weakness, interference with normal red blood cells).
Beware of unreliable sources. Allergy Research Group is a reliable source.
In particular: http://www.artemisin.com/artemisinin.pdf
Poly-MVA is a liquid compound created by Dr. Merrill Garnett. It is a combination of palladium, molybdenum, ruthenium, rhodium, lipoic acid, acetyl cysteine, formyl methionine, vitamin A, thiamine (B1), B2 and B12. PolyMVA is fairly expensive and appears to be effective in slightly over 50% of all cancer cases. Poly-MVA is used and recommended by some well known and reputable doctors (including Dr. Stephen Sinatra and Dr. Forsythe). Poly-MVA is expensive, be careful to not purchase a "fake" version. As of June 2010, the "sale" price is $150 (slightly less than half the "normal" old price) for 8 ounces (one bottle is about one week's dosage) http://www.polymva.com/
One major "problem" with Poly-MVA therapy is that it is recommended to minimize usage of anti-oxidants (vitamin C, vitamin E, lipoic acid) during usage of Poly-MVA or to separate dosages by at least six hours.
Breast tissue is adipose (fat) tissue. Aromatase in fat cells converts testosterone into estrogen (which then encourages tumor cells to grow rapidly). Being overweight is a major contributor to an improper balance of estrogen to testosterone.
Oxygen / Blood Coagulation
One factor that promotes cancer seems to get very little attention. That is oxygen delivery to tissues. Commonly we find in cancer patients a problem with thick "sludge" blood. I recommend testing fibrinogen levels to get an idea about your blood coagulation status. A number of nutrients help to improve blood flow: omega 3s, vitamin E, various enzymes (nattokinase, lumbrokinase and others).
L-Carnitine has also been shown to lower C-reactive protein and fibrinogen levels. [Source: http://www.nhiondemand.com/hsjarticle.aspx?id=912]
One saying I've liked to keep in mind is "More oxygen, less cancer". This is a great mantra for remembering to do "deep breathing" every day.
Turmeric - Curcumin
Turmeric - Curcumin have been widely studied and shown to reduce inflammation and improve health in a variety of ways. Turmeric is well known to fight cancer. Research reported in November 2009 [PMID: 19898931], indicates a major reason may be curcumin's impact on cancer stem cells. Chemotherapy's failure to kill cancer stem cells is widely considered to be one of the reasons chemotherapy fails.
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